Who would be the villain in the Madonna biopic?

Virtually every film about musicians (real or fictional) has an antagonist who threatens to destroy the finances/careers/lives of the central character(s). Because Madonna has avoided falling into a lot of the traps that destroyed her peers and has always been business-minded it’s hard to imagine some strong individual oppositional force in her life. However, films need conflict.

Do you think there’s a real life individual who could be portrayed as an antagonist in a Madonna biopic, or do you think the “opposition” portrayed in a Madonna biopic would be more systemic (sexism/ageism/rock purism)?